5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid

Base Information

• Chemical Name: 5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid
• CAS No.: 886221-47-2
• Molecular Formula: C₁₃H₁₂N₂O₅
• Molecular Weight: 276.249
• Mol file: 886221-47-2.mol

Synonyms:5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid

Chemical Property of 5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid

There total 1 articles about 5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 2-ethoxy(1-phenyl-2,5-dioxoimidazolidin-4-ylidene)ethanoate → 5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid (886221-47-2)

Guidance literature:

With potassium hydroxide; Heating;

DOI:10.1055/s-2006-926414

Reference yield: 90.0%

5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid (886221-47-2) + ethanol (64-17-5) → ethyl 5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylate (886221-49-4)

Guidance literature:

ethanol; With acetyl chloride; at 20 ℃;

5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid; Heating;

DOI:10.1055/s-2006-926414

Reference yield:

5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylic acid (886221-47-2) → 5-ethoxy-6-oxo-1,2-diphenyl-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1.1: AcCl / 20 °C

1.2: 90 percent / Heating

2.1: 73 percent / POCl₃; N,N-dimethylaniline / Heating; microwave irradiation

3.1: 84 percent / [(t-Bu)3PH]BF₄; KF / Pd₂(dba)3 / dioxane / 0.33 h / 135 °C

With potassium fluoride; N,N-dimethyl-aniline; acetyl chloride; tri tert-butylphosphoniumtetrafluoroborate; trichlorophosphate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,4-dioxane; 3.1: Suzuki coupling;

DOI:10.1055/s-2006-926414

Downstream raw materials:

ethyl 5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylate

ethyl 2-chloro-5-ethoxy-2-hydroxy-6-oxo-1-phenyl-1,6-dihydropyrimidine-4-carboxylate