Technology Process of 5-[(2,6-difluoro-3,5-dimethoxyphenyl)ethynyl]pyrimidin-2-amine
There total 5 articles about 5-[(2,6-difluoro-3,5-dimethoxyphenyl)ethynyl]pyrimidin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 1h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Selectfluor / acetonitrile / 12 h / 20 °C / Cooling with ice
2: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); Selectfluor; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C
1.2: 1 h / 0 - 25 °C
2.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 16 h / 40 °C / Inert atmosphere; Sealed tube
3.1: cesium fluoride / tetrahydrofuran; methanol / 1 h / 25 °C / Inert atmosphere
4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; sodium nitrite;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
