1445-39-2

Basic information

• Product Name: 2-AMINO-5-IODOPYRIMIDINE
• Synonyms: 2-AMINO-5-IODOPYRIMIDINE;5-Iodo-2-pyrimidinamine;2-Amino-5-iodopyrimidine,97%;5-iodopyrimidin-2-amine;5-Iodo-pyriMidin-2-ylaMine;2-PyriMidinaMine,5-iodo-;5-Iodopyrimidin-2-amine, 2-Amino-5-iodo-1,3-diazine
• CAS NO: 1445-39-2
• Molecular Formula: C₄H₄IN₃
• Molecular Weight: 221
• EINECS: -0
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyrimidine series;Pyrimidine;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines;Heterocycle-Pyrimidine series
• Mol File: 1445-39-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 219 °C
• Boiling Point: 364.9 °C at 760 mmHg
• Flash Point: 174.5 °C
• Appearance: cream to brown crystalline powder
• Density: 2.204 g/cm³
• Vapor Pressure: 1.63E-05mmHg at 25°C
• Refractive Index: 1.719
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.08±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-AMINO-5-IODOPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-IODOPYRIMIDINE(1445-39-2)
• EPA Substance Registry System: 2-AMINO-5-IODOPYRIMIDINE(1445-39-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 37/39-26-39
• WGK Germany: 3
• Hazardous Substances Data: 1445-39-2(Hazardous Substances Data)

Usage

Chemical Properties

cream to brown crystalline powder

Uses

2-Amino-5-iodopyrimidine is used as a reactant in the synthesis of aminopyrimidine and cyclic guanidine amino acids.

InChI:InChI=1/C4H4IN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)

Upstream product

• 109-12-6 2-aminopyrimidine 
• 1600-27-7 mercury(II) diacetate 
• 7732-18-5 water 

Downstream Products

• 857265-74-8 5-ethynylpyrimidine-2-amine 
• 890021-33-7 5-(3-fluoro-4-methoxyphenyl)pyrimidin-2-amine 
• 1448459-81-1 N,N-dibenzyl-5-iodopyrimidin-2-amine 
• 1448459-82-2 5-iodo-N,N-bis(4-methoxybenzyl)pyrimidin-2-amine 
• 265664-56-0 5-(tributylstannyl)pyrimidin-2-amine 
• 874494-43-6 5-(4-nitro-phenylsulfanyl)-pyrimidin-2-ylamine 
• 2362008-83-9 (2-aminopyrimidin-5-yl)dimethylphosphine oxide 

Relevant articles and documents

Pyrimidine or pyridine pyridine ketone compound and its preparation method and application (by machine translation)

The invention discloses a kind of type I of the pyrimidine or pyridine pyridine ketone compound and its preparation and application, which belongs to the technical field of pharmaceutical preparation. The compounds have high-efficient and selectively inhibit the cell cycle dependent kinases (Cdks) CDK4 and CDK6 active, and then by inhibiting CDK4/CDK6 prevent tumor cell division. Therefore, the compounds of this invention can be used for CDK4 and CDK6 the involved in cell cycle control disorders result in various diseases, especially suitable for the treatment of malignant tumors. (by machine translation)

A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants

(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.

IODINATION OF SOME DIAZINES AND DIAZINE N-OXIDES

A number of monosubstituted pyrazines, pyrimidines, and their N-oxides having the electron-donating amino groups were successfully iodinated.Depending on the reaction conditions, the 3-substituted pyrazine 1-oxides having a bulky dialkylamino group yielded the 6-iodo and 2,6-diiodopyrazine N-oxide derivatives together with some deoxygenated products.The mechanism with supportive evidence was presented to account for these chemical transformations.