1445-39-2

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-IODOPYRIMIDINE is used as a reactant in the synthesis of aminopyrimidine and cyclic guanidine amino acids. These synthesized compounds are essential building blocks for the development of new pharmaceuticals, particularly those targeting various diseases and medical conditions. The unique structure of 2-AMINO-5-IODOPYRIMIDINE allows for the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
In addition to its pharmaceutical applications, 2-AMINO-5-IODOPYRIMIDINE is also used as a reactant in chemical research. Its reactivity and unique structural features make it a valuable compound for exploring new reaction pathways and developing innovative synthetic methods. This can lead to the discovery of new chemical entities with potential applications in various industries, including materials science, agriculture, and environmental science.

InChI:InChI=1/C4H4IN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)

Upstream product

• 109-12-6 2-aminopyrimidine 
• 1600-27-7 mercury(II) diacetate 
• 7732-18-5 water 

Downstream Products

• 90841-92-2 N-(5-iodo-pyrimidin-2-yl)-benzenesulfonamide 
• 874494-43-6 5-(4-nitro-phenylsulfanyl)-pyrimidin-2-ylamine 
• 857265-74-8 5-ethynylpyrimidine-2-amine 
• 857266-56-9 tert-butyl (N-methyl)-3-[(2-aminopyrimidin-5-yl)ethynyl]phenylcarbamate 
• 890021-33-7 5-(3-fluoro-4-methoxyphenyl)pyrimidin-2-amine 
• 742700-78-3 5-(4-chloro-3-nitrophenyl)-2-pyrimidinamine 
• 956499-77-7 2-(4'-hydroxyphenyl)-6-iodoimidazo[1,2-a]pyrimidine 
• 1147938-92-8 N-(3-(7-(4-((dimethylamino)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzamide 
• 1181621-08-8 N-(3-((2-aminopyrimidin-5-yl)ethynyl)phenyl)-2-(3-(trifluoromethyl)phenyl)hydrazinecarboxamide 
• 1181621-11-3 2-(3-((2-aminopyrimidin-5-yl)ethynyl)phenyl)-N-(3-(trifluoromethyl)phenyl)hydrazinecarboxamide 
• 1181621-07-7 N-(3-((2-aminopyrimidin-5-yl)ethynyl)phenyl)-2-(3-fluorophenyl)hydrazinecarboxamide 
• 402960-38-7 5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine 
• 1316221-26-7 methyl 4-(5-iodopyrimidin-2-ylcarbamoyl)benzoate 
• 1361537-64-5 5-(4-phenylbut-1-ynyl)pyrimidin-2-amine 

Relevant academic research and scientific papers

Pyrimidine or pyridine pyridine ketone compound and its preparation method and application (by machine translation)

The invention discloses a kind of type I of the pyrimidine or pyridine pyridine ketone compound and its preparation and application, which belongs to the technical field of pharmaceutical preparation. The compounds have high-efficient and selectively inhibit the cell cycle dependent kinases (Cdks) CDK4 and CDK6 active, and then by inhibiting CDK4/CDK6 prevent tumor cell division. Therefore, the compounds of this invention can be used for CDK4 and CDK6 the involved in cell cycle control disorders result in various diseases, especially suitable for the treatment of malignant tumors. (by machine translation)

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants

(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.

Use of pK(a) differences to enhance the formation of base triplets involving C-G and G-C base pairs

Two C-nucleosides are employed for the recognition of dC-dG base pairs. Both derivatives are related to dC but lack the O2-carbonyl. The absence of the carbonyl should eliminate any unfavorable steric interactions at this site. One of the derivatives contains a 2-aminopyridine heterocycle (d2APy) while the second contains a 2-aminopyrimidine heterocycle (d2APm). The former with a pK(a) of 6.8 functions better for the recognition of dG-dC base pairs than it does in the binding to dC-dG base pairs. The d2APm derivative with a pK(a) of 3.3 functions better to form base triplets with dC-dG base pairs than with dG-dC targets. Triplex T(m)'s in both cases are compared with the sequence containing the native dC residue. The dC analogues appear to make two hydrogen bonds to a target dG base residue, one of which requires protonation of the ring nitrogen. Recognition of a target dC residue appears to require the formation of a single hydrogen bond to the C-nucleoside and having, that nitrogen largely in the unprotonated state facilitates its formation.

IODINATION OF SOME DIAZINES AND DIAZINE N-OXIDES

A number of monosubstituted pyrazines, pyrimidines, and their N-oxides having the electron-donating amino groups were successfully iodinated.Depending on the reaction conditions, the 3-substituted pyrazine 1-oxides having a bulky dialkylamino group yielded the 6-iodo and 2,6-diiodopyrazine N-oxide derivatives together with some deoxygenated products.The mechanism with supportive evidence was presented to account for these chemical transformations.