N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine

Base Information

• Chemical Name: N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine
• CAS No.: 719288-80-9
• Molecular Formula: C₃₆H₃₉N₅O₉S
• Molecular Weight: 717.8

Synonyms:N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine

Chemical Property of N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine

Chemical Property:

Purity/Quality:

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Technology Process of N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine

There total 12 articles about N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N2-isobutyryl-2'-deoxyxyloguanosine (181269-04-5) + 4,4'-dimethoxytrityl chloride (40615-36-9) + methanesulfonyl chloride (124-63-0) → N2-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine (719288-80-9)

Guidance literature:

N²-isobutyryl-2'-deoxyxyloguanosine; 4,4'-dimethoxytrityl chloride; With pyridine; at 20 ℃; for 2h;

methanesulfonyl chloride; With pyridine; at 4 ℃; for 1h;

DOI:10.1021/ol070147w

Reference yield:

N2-isobutyryl-2'-deoxyguanosine (64350-24-9) → N2-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine (719288-80-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 61 g / pyridine / 20 °C

2: 63 percent / DMAP / CH₂Cl₂ / 1 h / 20 °C

3: 86 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

4: 79 percent / pyridine / 3 h

5: L-Selectride(R) / tetrahydrofuran

6: 73 percent / pyridine

With pyridine; dmap; tetrabutyl ammonium fluoride; L-Selectride; In tetrahydrofuran; dichloromethane;

DOI:10.1081/NCN-120027826

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N2-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine (719288-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / pyridine / 3 h

2: L-Selectride(R) / tetrahydrofuran

3: 73 percent / pyridine

With pyridine; L-Selectride; In tetrahydrofuran;

DOI:10.1081/NCN-120027826

upstream raw materials:

N²-isobutyryl-2'-deoxyxyloguanosine

4,4'-dimethoxytrityl chloride

methanesulfonyl chloride

N²-isobutyryl-2'-O-methanesulfonylguanosine

Downstream raw materials:

3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

N²-isobutyryl-3'-S-benzoyl-2',3'-dideoxy-3'-thioguanosine

N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-S-benzoyl-2',3'-dideoxy-3'-thioguanosine

3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

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