3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether

Base Information

• Chemical Name: 3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether
• CAS No.: 572874-28-3
• Molecular Formula: C₂₁H₄₂N₂OSi₂
• Molecular Weight: 394.748
• Mol file: 572874-28-3.mol

Synonyms:3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether

Chemical Property of 3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether

There total 1 articles about 3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

trimethylsilyl trifluoromethanesulfonate (27607-77-8) + 1,3-bis(dimethylaminomethyl)-5-((tert-butyldimethylsilyl)oxy)benzene (182629-21-6) → 3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether (572874-28-3)

Guidance literature:

1,3-bis(dimethylaminomethyl)-5-((tert-butyldimethylsilyl)oxy)benzene; With n-butyllithium; In hexane; at 20 ℃; for 4h;

trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Further stages.;

DOI:10.1002/ejoc.200210601

Reference yield: 60.0%

meta-bromobenzyl bromide (823-78-9) + 3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether (572874-28-3) → 5-(3-bromobenzyloxy)-1,3-bis[(dimethylamino)methyl]-2-(trimethylsilyl)benzene

Guidance literature:

With 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran;

DOI:10.1002/ejoc.200210601

Reference yield:

1-hydroxypyrene (5315-79-7) + 1-bromo-3,5-bis(bromomethyl)benzene (51760-23-7) + 3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether (572874-28-3) → C40H25BrO2 (572874-27-2) + 1-[3-({3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyloxy}methyl)-5-bromobenzyloxy]pyrene

Guidance literature:

1-hydroxypyrene; 1-bromo-3,5-bis(bromomethyl)benzene; With 18-crown-6 ether; In tetrahydrofuran; at 20 ℃; for 18h;

3,5-bis[(dimethylamino)methyl]-4-(trimethylsilyl)phenyl tert-butyldimethylsilyl ether; With 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; for 18h;

DOI:10.1002/ejoc.200210601

upstream raw materials:

trimethylsilyl trifluoromethanesulfonate

1,3-bis(dimethylaminomethyl)-5-((tert-butyldimethylsilyl)oxy)benzene

Downstream raw materials:

C₄₀H₂₅BrO₂