51760-23-7

Usage

Uses

Used in Pharmaceutical Industry:
Benzene, 1-bromo-3,5-bis(bromomethyl)is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the formation of new chemical entities with potential therapeutic applications. Benzene, 1-bromo-3,5-bis(bromomethyl)-'s reactivity and versatility make it a valuable building block for the development of novel drugs.
Used in Agrochemical Industry:
In the agrochemical industry, Benzene, 1-bromo-3,5-bis(bromomethyl)is employed as a precursor for the synthesis of various agrochemicals, including pesticides and herbicides. Its ability to form stable and effective compounds makes it a valuable component in the development of new agricultural products.
Used in Polymer Industry:
Benzene, 1-bromo-3,5-bis(bromomethyl)is utilized as a monomer or building block in the production of polymers and other industrial chemicals. Its presence in the polymer chain can impart specific properties, such as flame retardancy, thermal stability, or chemical resistance, making it suitable for various applications in the polymer industry.
Used in Organic Synthesis:
As an intermediate in organic synthesis, Benzene, 1-bromo-3,5-bis(bromomethyl)is employed in the preparation of a wide range of organic compounds. Its reactivity allows for various chemical transformations, enabling the synthesis of complex molecules with diverse applications in different industries.
Safety Precautions:
Due to the potential toxicity and environmental impact of Benzene, 1-bromo-3,5-bis(bromomethyl)-, it is essential to follow proper safety measures when handling and using Benzene, 1-bromo-3,5-bis(bromomethyl)-. This includes wearing appropriate personal protective equipment (PPE), working in a well-ventilated area, and disposing of the compound according to local regulations and guidelines. Additionally, it is crucial to minimize exposure to the compound and to handle it with care to prevent any adverse effects on human health and the environment.

Upstream product

• 556-96-7 5-bromo-1,3-xylene 
• 23351-91-9 5-bromoisophthalic acid 
• 51760-21-5 dimethyl 5-bromoisophthalate 

Downstream Products

• 469890-01-5 tetramethyl [(5-bromo-1,3-phenylene)bis-(methylene)]bis-phosphonate 
• 108835-03-6 1-bromo-3,5-bis(chloromethyl)benzene 
• 317334-99-9 1,1'-((5-bromo-1,3-phenylene)bis(methylene))bis(1H-pyrazole) 
• 1225050-74-7 C₂₈H₃₃BrO₂ 
• 1268263-23-5 3,5-bis[(N,N-diisopropylamino)methyl]phenylboronic acid 
• 1338978-76-9 2,5-dioxopyrrolidin-1-yl-3,5-bis(phenylthiomethyl)benzoate 
• 654671-08-6 3,5-bis(phenylthiomethyl)bromobenzene 
• 1312229-47-2 1-bromo-3,5-di-n-tridecyl-benzene 
• 1312229-49-4 3,5-di-n-tridecyl-benzaldehyde 
• 1312229-53-0 [5,15-bis(3,5-di-n-tridecylphenyl)-porphyrinato(2-)-κN21,κN22,κN23,κN24] zinc(II) 
• 1134206-45-3 HP(O)(C₆H₃-bis-m,m-CH₂NMe₂)2 

Relevant academic research and scientific papers

New fluorescent tetraphenylporphyrin-based dendrimers with alkene-linked fluorenyl antennae designed for oxygen sensitization

The design of porphyrin-based dendrimers featuring conjugated fluorenyl dendrons via alkene spacers allows evaluating the importance of the role of these spacers on the optical properties of interest. In the continuation of previous studies, a second-gene

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens

Pentamidine, an FDA-approved antiparasitic drug, was recently identified as an outer membrane disrupting synergist that potentiates erythromycin, rifampicin, and novobiocin against Gram-negative bacteria. The same study also described a preliminary structure-activity relationship using commercially available pentamidine analogues. We here report the design, synthesis, and evaluation of a broader panel of bis-amidines inspired by pentamidine. The present study both validates the previously observed synergistic activity reported for pentamidine, while further assessing the capacity for structurally similar bis-amidines to also potentiate Gram-positive specific antibiotics against Gram-negative pathogens. Among the bis-amidines prepared, a number of them were found to exhibit synergistic activity greater than pentamidine. These synergists were shown to effectively potentiate the activity of Gram-positive specific antibiotics against multiple Gram-negative pathogens such as Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, including polymyxin- and carbapenem-resistant strains.

ENDOSOMOLYTIC AGENTS FOR GENE THERAPY

Compounds of formula (I), wherein Ar is an aryl group optionally further substituted with one or more groups R3; A is a lipophilic, hydrophobic moiety; R1 is a phosphodiester, phosphotriester, thioether or amide group; X is an unsubs

Structure-guided design of selective inhibitors of neuronal nitric oxide synthase

Nitric oxide synthases (NOSs) comprise three closely related isoforms that catalyze the oxidation of l-arginine to l-citrulline and the important second messenger nitric oxide (NO). Pharmacological selective inhibition of neuronal NOS (nNOS) has the potential to be therapeutically beneficial in various neurodegenerative diseases. Here, we present a structure-guided, selective nNOS inhibitor design based on the crystal structure of lead compound 1 in nNOS. The best inhibitor, 7, exhibited low nanomolar inhibitory potency and good isoform selectivities (nNOS over eNOS and iNOS are 472-fold and 239-fold, respectively). Consistent with the good selectivity, 7 binds to nNOS and eNOS with different binding modes. The distinctly different binding modes of 7, driven by the critical residue Asp597 in nNOS, offers compelling insight to explain its isozyme selectivity, which should guide future drug design programs.

Synthesis of S-acetyl oligo-p-aryleneethynylene tetrathiols

A novel class of tetrathiolated aryleneethynylene oligomers was obtained by the Cassar-Heck-Sonogashira coupling between S,S-(5-ethynyl-1,3-phenylene) bis(methylene)diethanethioate (1) and aryl diiodides or dibromides. Although standard coupling condition