(S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide
• CAS No.: 1026611-81-3
• Molecular Formula: C₁₂H₂₃NOS
• Molecular Weight: 229.387
• Mol file: 1026611-81-3.mol

Synonyms:(S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide

Chemical Property of (S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide

There total 1 articles about (S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cyclohexylacetaldehyde (5664-21-1) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide (1026611-81-3)

Guidance literature:

With pyridinium p-toluenesulfonate; magnesium sulfate; In dichloromethane; for 12h;

DOI:10.1021/acs.jmedchem.8b00674

Reference yield: 57.0%

(S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide (1026611-81-3) + trimethylsilylacetylene (1066-54-2) → (S)-N-((S)-1-cyclohexyl-4-(trimethylsilyl)but-3-yn-2-yl)-2-methylpropane-2-sulfinamide

Guidance literature:

trimethylsilylacetylene; With methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 - 30 ℃; for 1.33333h; Inert atmosphere;

(S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide; In tetrahydrofuran; diethyl ether; dichloromethane; at -78 - 20 ℃; for 4.25h; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/cmdc.202000793

Reference yield: 31.0%

isopropylmagnesium chloride (1068-55-9) + (S)-N-[(1E)-2-cyclohexylethylidene]-2-methylpropane-2-sulfinamide (1026611-81-3) → (S)-N-[(1S)-1-(cyclohexylmethyl)-2-methylpropyl]-2-methylpropane-2-sulfinamide

Guidance literature:

In tetrahydrofuran; dichloromethane; at -78 - 20 ℃; stereoselective reaction;

DOI:10.1021/acs.jmedchem.8b00674

upstream raw materials:

cyclohexylacetaldehyde

(S)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(S)-1-Cyclohexylmethyl-allylamine

N-(2-cyclohexyl-1-oxiranyl-ethyl)-benzamide

N-(1-cyclohexylmethyl-allyl)-3-phenyl-propionamide

N-(2-cyclohexyl-1-oxiranyl-ethyl)-3-phenyl-propionamide