1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid
CAS No.:1246536-41-3
Molecular Formula:C₁₆H₂₀O₇
Molecular Weight:324.331
Hs Code.:

Synonyms:1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid

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Chemical Property of 1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid

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Technology Process of 1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid

There total 4 articles about 1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 77095-01-3
2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

: 1246536-41-3
1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; at 30 ℃; for 0.5h;
DOI:10.1021/jm301864s

Reference yield:

: 51444-50-9
diethyl 2-(3,4,5-trimethoxybenzylidene)malonate

: 1246536-41-3
1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.08 h

1.2: 0.17 h / 60 °C / Microwave irradiation

2.1: potassium hydroxide / water; ethanol / 0.5 h / 30 °C

With sodium hydride; potassium hydroxide; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm301864s

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1246536-41-3
1-(ethoxycarbonyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine; acetic acid / toluene / 12 h / Reflux

2.1: sodium hydride / dimethyl sulfoxide / 0.08 h

2.2: 0.17 h / 60 °C / Microwave irradiation

3.1: potassium hydroxide / water; ethanol / 0.5 h / 30 °C

With piperidine; sodium hydride; acetic acid; potassium hydroxide; In ethanol; water; dimethyl sulfoxide; toluene;
DOI:10.1021/jm301864s