2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

Base Information

Chemical Name:2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester
CAS No.:77095-01-3
Molecular Formula:C₁₈H₂₄O₇
Molecular Weight:352.384
Hs Code.:

Synonyms:2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

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Chemical Property of 2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

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Technology Process of 2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

There total 3 articles about 2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 51444-50-9
diethyl 2-(3,4,5-trimethoxybenzylidene)malonate

: 1774-47-6
trimethylsulfoxonium iodide

: 77095-01-3
2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; Inert atmosphere;

diethyl 2-(3,4,5-trimethoxybenzylidene)malonate; In dimethyl sulfoxide; mineral oil; at 15 - 60 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2010.05.034

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 77095-01-3
2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine; acetic acid / toluene / 12 h / Reflux

2.1: sodium hydride / dimethyl sulfoxide / 0.08 h

2.2: 0.17 h / 60 °C / Microwave irradiation

With piperidine; sodium hydride; acetic acid; In dimethyl sulfoxide; toluene;
DOI:10.1021/jm301864s

Reference yield:

: 105-53-3
diethyl malonate

: 77095-01-3
2-(3,4,5-trimethoxyphenyl)cyclopropane-1,1-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine; acetic acid / toluene / 12 h / Reflux

2.1: sodium hydride / dimethyl sulfoxide / 0.08 h

2.2: 0.17 h / 60 °C / Microwave irradiation

With piperidine; sodium hydride; acetic acid; In dimethyl sulfoxide; toluene;
DOI:10.1021/jm301864s