1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane

Base Information

Chemical Name:1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane
CAS No.:501019-77-8
Molecular Formula:C₄₀H₅₈N₄O₁₀
Molecular Weight:754.921
Hs Code.:

Synonyms:1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane

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Chemical Property of 1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane

Chemical Property:

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Technology Process of 1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane

There total 1 articles about 1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

: 2783-17-7,95931-03-6
1,12-Diaminododecane

: 5672-83-3
Z-L-GluOMe

: 501019-77-8
1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/ja026264y

Reference yield:

: 501019-77-8
1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane

: (S)-4-{12-[(S)-4-Carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-dodecylcarbamoyl}-2-(4-methylamino-benzoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 97.9 percent / H₂; HCl / 10 percent Pd/C / methanol / 2.5 h

2: 88.8 percent / DCC; 1-hydroxybenzotriazole hydrate; N-methylmorpholine / dimethylformamide / 23 h / 0 - 20 °C

3: NaOH / ethanol; H₂O / 3 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; 10 percent Pd/C; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja026264y

Reference yield:

: 501019-77-8
1,12-di-(4-benzyloxycarbonylamino-4-(4S)-methoxycarbonyl-butyrylamino)dodecane

: 501019-78-9
1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

Guidance literature:: Multi-step reaction with 2 steps

1: 97.9 percent / H₂; HCl / 10 percent Pd/C / methanol / 2.5 h

2: 88.8 percent / DCC; 1-hydroxybenzotriazole hydrate; N-methylmorpholine / dimethylformamide / 23 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; 10 percent Pd/C; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja026264y