1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

Base Information

Chemical Name:1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane
CAS No.:501019-78-9
Molecular Formula:C₄₄H₅₈F₆N₆O₁₀
Molecular Weight:944.969
Hs Code.:

Synonyms:1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

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Chemical Property of 1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

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Technology Process of 1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

There total 4 articles about 1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.8%

: 50734-07-1
4-[N-methyl-N-(trifluoroacetyl)amino]benzoic acid

: (S)-2-Amino-4-[12-((S)-4-amino-4-methoxycarbonyl-butyrylamino)-dodecylcarbamoyl]-butyric acid methyl ester

: 501019-78-9
1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

Guidance literature:: With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 23h;
DOI:10.1021/ja026264y

Reference yield:

: 2783-17-7,95931-03-6
1,12-Diaminododecane

: 501019-78-9
1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

Guidance literature:: Multi-step reaction with 3 steps

1: 89.2 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

2: 97.9 percent / H₂; HCl / 10 percent Pd/C / methanol / 2.5 h

3: 88.8 percent / DCC; 1-hydroxybenzotriazole hydrate; N-methylmorpholine / dimethylformamide / 23 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; 10 percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja026264y

Reference yield:

: 5672-83-3
Z-L-GluOMe

: 501019-78-9
1,12-di-(4-(4S)-methoxycarbonyl-4-[4-(methyl(trifluoroacetyl)amino)benzoylamino]butyrylamino)dodecane

Guidance literature:: Multi-step reaction with 3 steps

1: 89.2 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

2: 97.9 percent / H₂; HCl / 10 percent Pd/C / methanol / 2.5 h

3: 88.8 percent / DCC; 1-hydroxybenzotriazole hydrate; N-methylmorpholine / dimethylformamide / 23 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; 10 percent Pd/C; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja026264y