(S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide

Base Information

• Chemical Name: (S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide
• CAS No.: 326498-83-3
• Molecular Formula: C₁₅H₁₉NO₂
• Molecular Weight: 245.321
• Mol file: 326498-83-3.mol

Synonyms:(S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide

Chemical Property of (S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide

There total 2 articles about (S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(S)-tert-leucinol (112245-13-3) + phenylpropyolic acid (637-44-5) → (S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide (326498-83-3)

Guidance literature:

phenylpropyolic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃;

(S)-tert-leucinol; In tetrahydrofuran;

DOI:10.1002/chem.201500397

Reference yield:

phenylpropyolic acid (637-44-5) → (S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide (326498-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N'-dicyclohexylcarbodiimide / dioxane / 2.5 h / 20 °C

2: dioxane / 15 h / 20 °C

With dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1016/S0957-4166(00)00409-2

Reference yield: 82.0%

(S)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-3-phenylpropiolamide (326498-83-3) → (S)-4-(tert-butyl)-2-(2-phenylethynyl)-1,3-oxazoline

Guidance literature:

With dmap; triethylamine; p-toluenesulfonyl chloride; In 1,2-dichloro-ethane; for 24h; Heating;

DOI:10.1016/S0957-4166(00)00409-2

upstream raw materials:

phenylpropyolic acid

(S)-tert-leucinol