N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,n1-dimethyl-ethanediamide

Base Information

• Chemical Name: N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,n1-dimethyl-ethanediamide
• CAS No.: 1380665-38-2
• Molecular Formula: C₂₆H₃₃FN₆O₇S
• Molecular Weight: 592.648

Synonyms:N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,n1-dimethyl-ethanediamide

Chemical Property of N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,n1-dimethyl-ethanediamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,n1-dimethyl-ethanediamide

There total 8 articles about N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,n1-dimethyl-ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[7-amino-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,N1-dimethyl-ethanediamide hydrochloride + Methanesulfonic anhydride (7143-01-3) → N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,n1-dimethyl-ethanediamide (1380665-38-2)

Guidance literature:

With triethylamine; In dichloromethane; for 1h;

Reference yield:

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester (1380665-18-8) → N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,n1-dimethyl-ethanediamide (1380665-38-2)

Guidance literature:

Multi-step reaction with 9 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 0.75 h

6: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

7: dichloromethane / 1 h / Inert atmosphere; Reflux

8: hydrogenchloride / water; tetrahydrofuran

9: triethylamine / dichloromethane / 1 h

With 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; hydrogen; sodium carbonate; Dess-Martin periodane; triethylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

C26H30FN5O7 (1380665-27-9) → N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N1,n1-dimethyl-ethanediamide (1380665-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; diphenyl phosphoryl azide / dichloromethane / 1 h / Inert atmosphere

2: dichloromethane / 1 h / Inert atmosphere; Reflux

3: hydrogenchloride / water; tetrahydrofuran

4: triethylamine / dichloromethane / 1 h

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

Methanesulfonic anhydride

C₂₆H₃₀FN₅O₇

N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-7-isocyanato-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

Downstream raw materials:

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-[(methylsulfonyl)amino]-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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