4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester

Base Information

• Chemical Name: 4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester
• CAS No.: 368443-76-9
• Molecular Formula: C₃₄H₃₆N₂O₅
• Molecular Weight: 552.67

Synonyms:4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester

Chemical Property of 4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester

There total 2 articles about 4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzylpyperidine (31252-42-3) + 3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-isobutoxycarbonyloxy-4-oxo-butyric acid allyl ester → 4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester (368443-76-9)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1039/b100401h

Reference yield:

N-alpha-(9-fluorenylmethyloxycarbonyl)-D-aspartic acid beta-allyl ester (177609-12-0) → 4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester (368443-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NMM / tetrahydrofuran / 0.08 h / -15 °C

2: NMM / tetrahydrofuran / 4 h / 0 - 20 °C

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.1039/b100401h

Reference yield:

4-(4-benzyl-piperidin-1-yl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butyric acid allyl ester (368443-76-9) → (2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartic α-4-benzylpiperidinylamide (368443-77-0)

Guidance literature:

With phenylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1039/b100401h

upstream raw materials:

4-benzylpyperidine

N-alpha-(9-fluorenylmethyloxycarbonyl)-D-aspartic acid beta-allyl ester

Downstream raw materials:

(2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartic α-4-benzylpiperidinylamide

cyclo{-(2S)-Phe-[(2R)-α-4-benzylpiperidinyl-Asp]-(2R)-α-OMe-Glu-γ-(2S)-Pro-β-(2R)-Asp-}

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