N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Base Information

Chemical Name:N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide
CAS No.:1450833-04-1
Molecular Formula:C₃₀H₃₆N₂O₄
Molecular Weight:488.627
Hs Code.:

Synonyms:N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

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Chemical Property of N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

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Technology Process of N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

There total 5 articles about N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1450834-13-5
C₅₁H₅₄N₂O₄

: 1450833-04-1
N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Guidance literature:: With hydrogenchloride; palladium on carbon; hydrogen; In methanol; water; at 20 ℃;
DOI:10.1016/j.bmc.2013.06.054

Reference yield:

: 537030-19-6
(2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide

: 1450833-04-1
N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / methanol

2: triethylamine / N,N-dimethyl-formamide / 6 h / 100 °C

3: hydrazine hydrate / ethanol / 3 h / Reflux

4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 5 h / 20 °C

5: palladium on carbon; hydrogenchloride; hydrogen / methanol; water / 20 °C

With hydrogenchloride; palladium on carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.06.054

Reference yield:

: 1450833-88-1
(4-{(2R,3R,4R)-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]pyrrolidin-1yl}butyl)amine

: 1450833-04-1
N-(4-((2R,3R,4R)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)butyl)-3,3,3-triphenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 5 h / 20 °C

2: palladium on carbon; hydrogenchloride; hydrogen / methanol; water / 20 °C

With hydrogenchloride; palladium on carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; water;
DOI:10.1016/j.bmc.2013.06.054