(S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate

Base Information

• Chemical Name: (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate
• CAS No.: 213531-20-5
• Molecular Formula: C₁₀H₁₂O₆S
• Molecular Weight: 260.268
• Mol file: 213531-20-5.mol

Synonyms:(S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate

Chemical Property of (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate

There total 2 articles about (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide (213531-26-1) → (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate (213531-20-5)

Guidance literature:

With ruthenium trichloride; sodium periodate; In water; acetonitrile; for 0.333333h; Ambient temperature;

DOI:10.1021/jo980471s

Reference yield:

(R)-3-(p-methoxyphenoxy)-1,2-propanediol (17131-52-1,124933-35-3,131064-88-5,131064-87-4) → (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate (213531-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂, pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 98 percent / NaIO₄, RuCl₃*H₂O / acetonitrile; H₂O / 0.33 h / Ambient temperature

With pyridine; ruthenium trichloride; sodium periodate; thionyl chloride; In dichloromethane; water; acetonitrile;

DOI:10.1021/jo980471s

Reference yield: 95.0%

hexadecylamine (143-27-1) + (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate (213531-20-5) → (R)-1-Hexadecylamino-3-(4-methoxy-phenoxy)-propan-2-ol

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/jo980471s

upstream raw materials:

(S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide

(R)-3-(p-methoxyphenoxy)-1,2-propanediol

Downstream raw materials:

1-O-hexadecyl-3-O-(p-methoxyphenyl)-sn-glycerol

1-O-(4'-methoxyphenyl)-3-bromo-1,2-propanediol

(R)-3-azido-1-O-(4'-methoxyphenyl)-1,2-propanediol

4-methoxybenzyloxy ester of (S)-glycidol

Refernces