(S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide

Base Information

• Chemical Name: (S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide
• CAS No.: 213531-26-1
• Molecular Formula: C₁₀H₁₂O₅S
• Molecular Weight: 244.268
• Mol file: 213531-26-1.mol

Synonyms:(S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide

Chemical Property of (S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide

There total 1 articles about (S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-3-(p-methoxyphenoxy)-1,2-propanediol (17131-52-1,124933-35-3,131064-88-5,131064-87-4) → (S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide (213531-26-1)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/jo980471s

Reference yield: 98.0%

(S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide (213531-26-1) → (S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate (213531-20-5)

Guidance literature:

With ruthenium trichloride; sodium periodate; In water; acetonitrile; for 0.333333h; Ambient temperature;

DOI:10.1021/jo980471s

Reference yield:

(S)-4-(4-Methoxy-phenoxymethyl)-[1,3,2]dioxathiolane 2-oxide (213531-26-1) → 4-methoxybenzyloxy ester of (S)-glycidol (2211-94-1,51469-79-5,71048-65-2,71031-04-4,26744-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / NaIO₄, RuCl₃*H₂O / acetonitrile; H₂O / 0.33 h / Ambient temperature

2: 1.) LiBr, 2.) aq. H₂SO₄ / 1.) THF, room temperature, 2.) Et₂O, room temperature, overnight

3: K₂CO₃ / methanol / 2 h / -23 °C

With ruthenium trichloride; sodium periodate; sulfuric acid; potassium carbonate; lithium bromide; In methanol; water; acetonitrile;

DOI:10.1021/jo980471s

upstream raw materials:

(R)-3-(p-methoxyphenoxy)-1,2-propanediol

Downstream raw materials:

(S)-1-(4'-methoxyphenyl)glycerol 2,3-cyclic sulfate

4-methoxybenzyloxy ester of (S)-glycidol

1-O-hexadecyl-3-O-(p-methoxyphenyl)-sn-glycerol

1-O-(4'-methoxyphenyl)-3-bromo-1,2-propanediol