3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

Base Information

Chemical Name:3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine
CAS No.:202929-85-9
Molecular Formula:C₂₇H₂₇N₅O₂
Molecular Weight:453.544
Hs Code.:

Synonyms:3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

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Chemical Property of 3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

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Technology Process of 3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

There total 6 articles about 3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202931-56-4
6-chloro-3-phenyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

: 202931-77-9
[3-(cyclopropylmethoxy)pyridin-2-yl]methanol

: 202929-85-9
3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

Guidance literature:: [3-(cyclopropylmethoxy)pyridin-2-yl]methanol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

6-chloro-3-phenyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm040883v

Reference yield:

: 14173-30-9
3-hydroxy-2-hydroxymethylpyridine hydrochloride

: 202929-85-9
3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: KOH / dimethylsulfoxide / 1 h / 0 °C

1.2: 2.40 g / dimethylsulfoxide / 0 - 20 °C

2.1: NaH / dimethylformamide / 20 °C

2.2: dimethylformamide / 20 °C

With potassium hydroxide; sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm040883v

Reference yield:

: 613-94-5
benzoic acid hydrazide

: 202929-85-9
3-phenyl-6-(3-cyclopropylmethyloxy-2-pyridyl)methyloxy-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / xylene / 96 h / Heating

2.1: NaH / dimethylformamide / 20 °C

2.2: dimethylformamide / 20 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm040883v