3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Base Information

• Chemical Name: 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine
• CAS No.: 162434-95-9
• Molecular Formula: C₅₅H₅₃N₁₄O₂₂P
• Molecular Weight: 1293.08
• Mol file: 162434-95-9.mol

Synonyms:3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property of 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

There total 3 articles about 3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3'-deoxy-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N6,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-94-8) → 3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N6,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-95-9)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; for 1h;

DOI:10.1002/hlca.19940770707

Reference yield:

3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{OP-[2-(4-nitrophenyl)ethyl]}->5')-2'-O-acetyl-3'-deoxy-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine (179397-59-2) → 3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N6,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-95-9)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1002/hlca.19960790305

Reference yield:

3'-deoxy-N6,2'-O-bis[2-(p-nitrophenyl)ethoxicarbonyl]adenosine (97776-94-8) + 3'-deoxy-5'-O-(monomethoxytrityl)-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite> (156046-19-4) → 3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N6,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (162434-95-9)

Guidance literature:

With 1H-tetrazole; iodine; toluene-4-sulfonic acid; Yield given. Multistep reaction; 1) CH₃CN; 2) H₂O; 3) CH₂Cl₂, MeOH;

DOI:10.1080/15257779508012544

upstream raw materials:

3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>-> 5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine

3'-deoxy-N⁶,2'-O-bis[2-(p-nitrophenyl)ethoxicarbonyl]adenosine

3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<2-(4-nitrophenyl)ethyl diisopropylphosphoramidite>

3'-deoxy-5'-O-[(4-methoxyphenyl)diphenylmethyl]-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenylyl-(2'-{O^P-[2-(4-nitrophenyl)ethyl]}->5')-2'-O-acetyl-3'-deoxy-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

Downstream raw materials:

3'-deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-<2'-P-<2-(4-nitrophenyl)ethyl>>->5'>-3'-deoxy-N⁶,2'-O-bis<2-(4-nit...