1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

Base Information

Chemical Name:1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene
CAS No.:470458-65-2
Molecular Formula:C₂₃H₃₇NO₃SSi
Molecular Weight:435.703
Hs Code.:

Synonyms:1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

Suppliers and Price of 1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

There total 8 articles about 1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: [3-(9-bora-bicyclo[3.3.1]non-9-yl)-propyl]-carbamic acid methyl ester

: 470458-64-1
1-(t-butyldimethylsiloxy)-2-bromo-3-phenylthio-2-cyclohexene

: 470458-65-2
1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

Guidance literature:: With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; for 3h; Heating;
DOI:10.1021/ol026671e

Reference yield:

: 75717-39-4
3-(phenylsulfanyl)cyclohex-2-en-1-one

: 470458-65-2
1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / N-bromosuccinimide / CCl₄ / 24 h / 20 °C

2: 96 percent / cerium chloride heptahydrate; sodium borohydride / methanol / 0.5 h / 20 °C

3: 77 percent / DMAP; DCC / CH₂Cl₂ / 4 h / 20 °C

4: 97 percent / LiBH₄ / tetrahydrofuran / 12 h / 20 °C

5: 95 percent / imidazole / dimethylformamide / 12 h / 20 °C

6: 83 percent / NaOH / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 3 h / Heating

With 1H-imidazole; dmap; sodium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; lithium borohydride; cerium(III) chloride; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; 6: Suzuki coupling reaction;
DOI:10.1021/ol026671e

Reference yield:

: 470458-71-0
2-bromo-3-(phenylsulfanyl)cyclohex-2-en-1-one

: 470458-65-2
1-(t-butyldimethylsiloxy)-2-(3'-carbomethoxyamino)propyl-3-phenylthio-2-cyclohexene

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / cerium chloride heptahydrate; sodium borohydride / methanol / 0.5 h / 20 °C

2: 77 percent / DMAP; DCC / CH₂Cl₂ / 4 h / 20 °C

3: 97 percent / LiBH₄ / tetrahydrofuran / 12 h / 20 °C

4: 95 percent / imidazole / dimethylformamide / 12 h / 20 °C

5: 83 percent / NaOH / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 3 h / Heating

With 1H-imidazole; dmap; sodium hydroxide; sodium tetrahydroborate; lithium borohydride; cerium(III) chloride; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5: Suzuki coupling reaction;
DOI:10.1021/ol026671e