6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid

Base Information

• Chemical Name: 6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid
• CAS No.: 164409-77-2
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.343
• Mol file: 164409-77-2.mol

Synonyms:6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid

Chemical Property of 6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid

There total 5 articles about 6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid methyl ester (164409-75-0) → 6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid (164409-77-2)

Guidance literature:

With lithium hydroxide; In ethanol; for 1h; Ambient temperature;

DOI:10.1080/00397919508013843

Reference yield:

methyl hex-5-ynoate (77758-51-1) → 6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid (164409-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 69.5 percent / Pd(PPh₃)4, Et₃N, CuI / 5 h / 75 - 80 °C

2: 73 percent / Pd(PPh₃)4, Et₃N, CuI / 11 h / 75 - 80 °C

3: 72 percent / aq. LiOH / ethanol / 1 h / Ambient temperature

With lithium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In ethanol;

DOI:10.1080/00397919508013843

Reference yield:

1,1-dimethylprop-3-ynylamine (2978-58-7) → 6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid (164409-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / Pd(PPh₃)4, Et₃N, CuI / 11 h / 75 - 80 °C

2: 72 percent / aq. LiOH / ethanol / 1 h / Ambient temperature

With lithium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In ethanol;

DOI:10.1080/00397919508013843

upstream raw materials:

6-[2-(3-Amino-3-methyl-but-1-ynyl)-phenyl]-hex-5-ynoic acid methyl ester

methyl hex-5-ynoate

1,1-dimethylprop-3-ynylamine

6-(2-Bromo-phenyl)-hex-5-ynoic acid methyl ester