4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole

Base Information

Chemical Name:4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole
CAS No.:1417902-11-4
Molecular Formula:C₁₉H₂₂N₂O₃S₂Si
Molecular Weight:418.613
Hs Code.:

Synonyms:4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole

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Chemical Property of 4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole

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Technology Process of 4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole

There total 1 articles about 4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1376711-44-2
5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazol-4-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1417902-11-4
4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole

Guidance literature:: With 1H-imidazole; In dichloromethane; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.016

Reference yield: 88.0%

: 1417902-11-4
4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole

: 1417902-15-8
4-(4-(((tert-butyl)dimethylsilyl)oxy)-2-(thiophen-2-yl)thiazol-5-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 50 ℃; under 7500.75 Torr; Autoclave;
DOI:10.1016/j.tet.2012.12.016

Reference yield:

: 1417902-11-4
4-(((tert-butyl)dimethylsilyl)oxy)-5-(4-nitrophenyl)-2-(thiophen-2-yl)thiazole

: 1-(4-(4-hydroxy-2-(thiophen-2-yl)thiazol-5-yl)phenyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 50 °C / 7500.75 Torr / Autoclave

2.1: triethylamine / ethanol / 0.5 h / 20 °C

2.2: 2 h / Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2012.12.016