α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide

Base Information

• Chemical Name: α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide
• CAS No.: 116078-64-9
• Molecular Formula: C₂₀H₃₂ClN₃O
• Molecular Weight: 365.947
• Mol file: 116078-64-9.mol

Synonyms:α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide

Chemical Property of α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide

There total 8 articles about α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanamide (116078-63-8) → α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide (116078-64-9)

Guidance literature:

With hydrogenchloride; phosphoric acid; hydrogen; Pd-BaSO₄; In ethanol; at 25 ℃; for 5h; under 4116.5 Torr;

DOI:10.1021/jm00119a017

Reference yield: 47.0%

(±)-α-(2-chlorophenyl)-α-[2-[(1-methylethyl)(allyl) amino]ethyl]-1-piperidinebutaneamide → α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide (116078-64-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; Wilkinson's catalyst; In ethanol; water; for 5h; Inert atmosphere; Reflux;

DOI:10.1021/op010217t

Reference yield:

2-(piperidin-4-yl)ethyl chloride (1932-03-2) → α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide (116078-64-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 38 percent / sodamide / toluene / 1.5 h / 80 °C

2: NaNH₂ / toluene / 2 h / 90 °C

3: 87 percent / conc. H₂SO₄ / 2.5 h / 95 - 100 °C

4: 91 percent / conc. HCl, H₃PO₄, hydrogen / Pd/BaSO₄ / ethanol / 5 h / 25 °C / 4116.5 Torr

With hydrogenchloride; phosphoric acid; sulfuric acid; hydrogen; sodium amide; Pd-BaSO₄; In ethanol; toluene;

DOI:10.1021/jm00119a017

upstream raw materials:

(+/-)-α-(2-chlorophenyl)-α-<2-<(1-methylethyl)(phenylmethyl)amino>ethyl>-1-piperidinebutanamide

2-(piperidin-4-yl)ethyl chloride

2-Chlorophenylacetonitrile

(±)-α-(2-chlorophenyl)-1-piperidinebutanenitrile

Downstream raw materials:

Bidisomide

(+/-)-α-<2-<(trifluoroacetyl)(1-methylethyl)amino>ethyl>-α-(2-chlorophenyl)-1-piperidinebutyronitrile

(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide