(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

Base Information

Chemical Name:(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide
CAS No.:116078-66-1
Molecular Formula:C₂₇H₃₆ClN₃O₂
Molecular Weight:470.055
Hs Code.:

Synonyms:(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

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Chemical Property of (+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

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Technology Process of (+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

There total 6 articles about (+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 98-88-4
benzoyl chloride

: 116078-64-9
α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide

: 116078-66-1
(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

Guidance literature:: With triethylamine; In chloroform; at 0 ℃; for 1h;
DOI:10.1021/jm00119a017

Reference yield:

: 1932-03-2
2-(piperidin-4-yl)ethyl chloride

: 116078-66-1
(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 38 percent / sodamide / toluene / 1.5 h / 80 °C

2: NaNH₂ / toluene / 2 h / 90 °C

3: 87 percent / conc. H₂SO₄ / 2.5 h / 95 - 100 °C

4: 91 percent / conc. HCl, H₃PO₄, hydrogen / Pd/BaSO₄ / ethanol / 5 h / 25 °C / 4116.5 Torr

5: 60 percent / Et₃N / CHCl₃ / 1 h / 0 °C

With hydrogenchloride; phosphoric acid; sulfuric acid; hydrogen; sodium amide; triethylamine; Pd-BaSO₄; In ethanol; chloroform; toluene;
DOI:10.1021/jm00119a017

Reference yield:

: 2856-63-5
2-Chlorophenylacetonitrile

: 116078-66-1
(+/-)-α-{2-[benzoyl(1-methylethyl)amino]ethyl}-α-(2-chlorophenyl)-1-piperidinebutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 38 percent / sodamide / toluene / 1.5 h / 80 °C

2: NaNH₂ / toluene / 2 h / 90 °C

3: 87 percent / conc. H₂SO₄ / 2.5 h / 95 - 100 °C

4: 91 percent / conc. HCl, H₃PO₄, hydrogen / Pd/BaSO₄ / ethanol / 5 h / 25 °C / 4116.5 Torr

5: 60 percent / Et₃N / CHCl₃ / 1 h / 0 °C

With hydrogenchloride; phosphoric acid; sulfuric acid; hydrogen; sodium amide; triethylamine; Pd-BaSO₄; In ethanol; chloroform; toluene;
DOI:10.1021/jm00119a017