4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid

Base Information

Chemical Name:4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid
CAS No.:251965-00-1
Molecular Formula:C₁₇H₁₃FO₄
Molecular Weight:300.286
Hs Code.:

Synonyms:4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid

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Chemical Property of 4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid

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Technology Process of 4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid

There total 7 articles about 4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 608537-05-9
4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid methyl ester

: 251965-00-1
4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;
DOI:10.1021/jm030559k

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 251965-00-1
4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 2.5 h / -70 °C

1.2: 95 percent / hexane; tetrahydrofuran / -78 - 20 °C

2.1: 84 percent / Et₃SiH; BF₃*Et₂O / CH₂Cl₂ / 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C

3.2: 63 percent / tetrahydrofuran; hexane / 0.5 h / -50 °C

4.1: MeONa / toluene; 1,2-dimethoxy-ethane / 60 °C

5.1: 1.79 g / aq. NaOH / tetrahydrofuran; methanol / 1 h / 20 °C

With triethylsilane; sodium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; sodium methylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; toluene;
DOI:10.1021/jm030559k

Reference yield:

: 698982-15-9
(3-bromophenyl)(2-fluorophenyl)methane

: 251965-00-1
4-[3-(2-fluorobenzyl)phenyl]-2,4-dioxobutyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 63 percent / tetrahydrofuran; hexane / 0.5 h / -50 °C

2.1: MeONa / toluene; 1,2-dimethoxy-ethane / 60 °C

3.1: 1.79 g / aq. NaOH / tetrahydrofuran; methanol / 1 h / 20 °C

With sodium hydroxide; n-butyllithium; sodium methylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; toluene;
DOI:10.1021/jm030559k