(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Base Information

Chemical Name:(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea
CAS No.:1429638-96-9
Molecular Formula:C₂₁H₂₅N₅O₄S
Molecular Weight:443.527
Hs Code.:

Synonyms:(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Suppliers and Price of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

There total 7 articles about (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 874297-79-7
1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1429639-75-7
2-chloro-4-[(3S)-3-methylmorpholin-4-yl]-6,7-dihydrothieno[3,2-d]pyrimidine 5,5-dioxide

: 1429638-96-9
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

: 7400-45-5
dimethyl-3-thiaadipate

: 1429638-96-9
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: lithium methanolate / 20 °C

2: sodium carbonate / water / 72 h / Darkness

3: water; hydrogenchloride; acetic acid / 110 °C

4: P,P-dichlorophenylphosphine oxide / 6 h / 130 - 140 °C

5: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C

7: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium methanolate; water; sodium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 7: |Suzuki Coupling;

Reference yield:

: 4900-98-5
2-(ethylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one

: 1429638-96-9
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: water; hydrogenchloride; acetic acid / 110 °C

2: P,P-dichlorophenylphosphine oxide / 6 h / 130 - 140 °C

3: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C

5: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; 5: |Suzuki Coupling;