Technology Process of 20-amino-3,6,9,12,15,18-hexaoxaicosanoic acid
There total 8 articles about 20-amino-3,6,9,12,15,18-hexaoxaicosanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-((17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)oxy)acetic acid;
With
triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 24h;
With
water;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide
2.1: potassium hydroxide / water; ethanol
3.1: potassium carbonate / N,N-dimethyl-formamide
4.1: potassium hydroxide / methanol
5.1: triphenylphosphine; ammonia; water / tetrahydrofuran
5.2: dowex 50W x 4(H+)
With
ammonia; water; sodium hydride; potassium carbonate; triphenylphosphine; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
5.1: |Staudinger Azide Reduction;
DOI:10.1016/j.tetlet.2013.06.065
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium azide / N,N-dimethyl-formamide / 15 h / 75 °C
2.1: sodium hydride / N,N-dimethyl-formamide
3.1: potassium hydroxide / water; ethanol
4.1: potassium carbonate / N,N-dimethyl-formamide
5.1: potassium hydroxide / methanol
6.1: triphenylphosphine; ammonia; water / tetrahydrofuran
6.2: dowex 50W x 4(H+)
With
sodium azide; ammonia; water; sodium hydride; potassium carbonate; triphenylphosphine; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
6.1: |Staudinger Azide Reduction;
DOI:10.1016/j.tetlet.2013.06.065
