(E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

Base Information

Chemical Name:(E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole
CAS No.:78329-49-4
Molecular Formula:C₁₇H₁₄ClN
Molecular Weight:267.758
Hs Code.:

Synonyms:(E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

Suppliers and Price of (E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

There total 6 articles about (E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17422-32-1
5-chloro-1H-indole

: 78329-49-4
(E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 88.5 percent / NaH / tetrahydrofuran / 1.) ice cooled, 2.) room temp., 2 h

2: Lithium diisopropylamine

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00332a019

Reference yield:

: 1530-32-1
ethyltriphenylphosphonium bromide

: (5-chloro-1H-indol-2-yl)(phenyl)methanone

: (Z)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

: 78329-49-4
(E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

Guidance literature:: ethyltriphenylphosphonium bromide; With sodium hydride; In toluene; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

(5-chloro-1H-indol-2-yl)(phenyl)methanone; In toluene; mineral oil; for 2h; Overall yield = 80 %; Overall yield = 645 mg; Reflux;
DOI:10.1002/adsc.201700092

Reference yield:

: C₁₅H₁₂ClNO

: (Z)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

: 78329-49-4
(E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / chloroform / 0.83 h / Reflux

2.1: sodium hydride / toluene; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 2 h / Reflux

With manganese(IV) oxide; sodium hydride; In chloroform; toluene; mineral oil;
DOI:10.1002/adsc.201700092