3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester

Base Information

Chemical Name:3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester
CAS No.:147219-64-5
Molecular Formula:C₂₃H₄₂O₃Si₂
Molecular Weight:422.756
Hs Code.:

Synonyms:3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester

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Chemical Property of 3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester

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Technology Process of 3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester

There total 1 articles about 3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 66737-88-0
4-hydroxy-3-tert-butyl benzoic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 147219-64-5
3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 1.) RT, 18 h, 2.) reflux, 18 h;
DOI:10.1021/jm00057a008

Reference yield: 100.0%

: 147219-64-5
3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester

: 142651-31-8
3-tert-butyl-4-(tert-butyldimethylsilyloxy)benzoyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm00057a008

Reference yield:

: 147219-64-5
3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester

: 147219-66-7
4-<carbonyl>-2-(1,1-dimethylethyl)phenyl octadecylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / oxalyl chloride, DMF / CH₂Cl₂ / 18 h / Ambient temperature

2: 1.) sodium hydride, HMPA / 1.) THF, 0 deg C, 15 min, 2.) THF, RT, 3.5 h

3: 81 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.) 0 deg C, 15 min, 2.) RT, 3 h

4: 88 percent / triethylamine / tetrahydrofuran / 22 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00057a008