(2'R)-N⁴-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine

Base Information

• Chemical Name: (2'R)-N⁴-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine
• CAS No.: 171815-04-6
• Molecular Formula: C₂₈H₄₃N₃O₆Si₂
• Molecular Weight: 574.829

Synonyms:(2'R)-N⁴-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine

Chemical Property of (2'R)-N⁴-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine

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Technology Process of (2'R)-N⁴-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine

There total 4 articles about (2'R)-N⁴-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-Bromo-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-uridine → (2'R)-N4-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine (171815-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 89 percent / Bu₃Sn⁽²⁾H, Et₃B / tetrahydrofuran; hexane / -60 - -52 °C

2: Et₃N / acetonitrile

3: NH₄OH / dioxane

4: pyridine

With pyridine; ammonium hydroxide; triethyl borane; tributyltin deuteride; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexane; acetonitrile;

DOI:10.1021/jo00126a058

Reference yield:

(2'-R)-[2'-2H]-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-β-D-uridine (156726-71-5) → (2'R)-N4-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine (171815-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / acetonitrile

2: NH₄OH / dioxane

3: pyridine

With pyridine; ammonium hydroxide; triethylamine; In 1,4-dioxane; acetonitrile;

DOI:10.1021/jo00126a058

Reference yield:

C23H38(2)HN5O5Si2 → (2'R)-N4-benzoyl-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine (171815-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OH / dioxane

2: pyridine

With pyridine; ammonium hydroxide; In 1,4-dioxane;

DOI:10.1021/jo00126a058

upstream raw materials:

benzoyl chloride

(2'R)-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-[2'-2H]cytidine

(2'-R)-[2'-2H]-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-β-D-uridine

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