(E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester
CAS No.:913171-87-6
Molecular Formula:C₁₅H₁₉Cl₂NO₃
Molecular Weight:332.227
Hs Code.:

Synonyms:(E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester

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Chemical Property of (E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester

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Technology Process of (E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester

There total 3 articles about (E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 913171-32-1
[3-(2,6-dichloro-4-iodo-phenoxy)-propyl]-dimethyl-amine

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 913171-87-6
(E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester

Guidance literature:: With 4 A molecular sieve; tetrabutylammomium bromide; potassium acetate; palladium diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1021/ol061599w

Reference yield:

: 540-38-5
p-Iodophenol

: 913171-87-6
(E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / di-iso-butylamine; SO₂Cl₂ / toluene / 1 h / 70 °C

2: 58 percent / Cs₂CO₃; NaI / acetonitrile / 12 h / 65 °C

3: 78 percent / tetrabutylammonium bromide; KOAc; molecular sieves 4 Angstroem / Pd(OAc)2 / dimethylformamide / 8 h / 20 °C

With diisobutylamine; sulfuryl dichloride; 4 A molecular sieve; tetrabutylammomium bromide; potassium acetate; caesium carbonate; sodium iodide; palladium diacetate; In N,N-dimethyl-formamide; toluene; acetonitrile; 3: Heck reaction;
DOI:10.1021/ol061599w

Reference yield:

: 34074-22-1
2,6-dichloro-4-iodophenol

: 913171-87-6
(E)-3-[3,5-Dichloro-4-(3-dimethylamino-propoxy)-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / Cs₂CO₃; NaI / acetonitrile / 12 h / 65 °C

2: 78 percent / tetrabutylammonium bromide; KOAc; molecular sieves 4 Angstroem / Pd(OAc)2 / dimethylformamide / 8 h / 20 °C

With 4 A molecular sieve; tetrabutylammomium bromide; potassium acetate; caesium carbonate; sodium iodide; palladium diacetate; In N,N-dimethyl-formamide; acetonitrile; 2: Heck reaction;
DOI:10.1021/ol061599w