1-Benzyl-3-acetylaminomethylindole

Base Information

• Chemical Name: 1-Benzyl-3-acetylaminomethylindole
• CAS No.: 118959-36-7
• Molecular Formula: C₁₈H₁₈N₂O
• Molecular Weight: 278.354
• Mol file: 118959-36-7.mol

Synonyms:1-Benzyl-3-acetylaminomethylindole

Chemical Property of 1-Benzyl-3-acetylaminomethylindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-3-acetylaminomethylindole

There total 3 articles about 1-Benzyl-3-acetylaminomethylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.3%

acetic anhydride (108-24-7) + 1-Benzyl-3-aminomethylindole (118959-34-5) → 1-Benzyl-3-acetylaminomethylindole (118959-36-7)

Guidance literature:

In benzene; for 12h; Heating;

DOI:10.1007/BF00763270

Reference yield:

1-Benzylindole-3-carboxaldehyde (10511-51-0) → 1-Benzyl-3-acetylaminomethylindole (118959-36-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NH₂OH*HCl, 2.) acetic anhydride / 1.) pyridine, 85 deg C, 2.) reflux, 2 h

2: 90.5 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 12 h / Heating

3: 50.3 percent / benzene / 12 h / Heating

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; acetic anhydride; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1007/BF00763270

Reference yield:

1-benzyl-1H-indole-3-carbonitrile (118959-33-4) → 1-Benzyl-3-acetylaminomethylindole (118959-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.5 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 12 h / Heating

2: 50.3 percent / benzene / 12 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1007/BF00763270

upstream raw materials:

acetic anhydride

1-Benzyl-3-aminomethylindole

1-Benzylindole-3-carboxaldehyde

1-benzyl-1H-indole-3-carbonitrile

Downstream raw materials:

1-Benzyl-3-ethylaminomethylindole