1-(Phenylmethyl)-1H-indole-3-methanamine

Base Information

Chemical Name:1-(Phenylmethyl)-1H-indole-3-methanamine
CAS No.:118959-34-5
Molecular Formula:C₁₆H₁₆N₂
Molecular Weight:236.316
Hs Code.:
DSSTox Substance ID:DTXSID501275871

Synonyms:1-(Phenylmethyl)-1H-indole-3-methanamine;DTXSID501275871;AKOS013787346;118959-34-5

Suppliers and Price of 1-(Phenylmethyl)-1H-indole-3-methanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Phenylmethyl)-1H-indole-3-methanamine

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:236.131348519
Heavy Atom Count:18
Complexity:260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN2C=C(C3=CC=CC=C32)CN

Technology Process of 1-(Phenylmethyl)-1H-indole-3-methanamine

There total 5 articles about 1-(Phenylmethyl)-1H-indole-3-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 118959-33-4
1-benzyl-1H-indole-3-carbonitrile

: 118959-34-5
1-Benzyl-3-aminomethylindole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 12h; Heating;
DOI:10.1007/BF00763270

Reference yield:

: N-benzyl indole-3-carbaldehyde oxime

: 118959-34-5
1-Benzyl-3-aminomethylindole

Guidance literature:: N-benzyl indole-3-carbaldehyde oxime; With nickel(II) chloride hexahydrate; In methanol;

With methanol; sodium tetrahydroborate; at 0 ℃; for 0.0833333h;
DOI:10.1039/c8nj02037j

Reference yield:

: 10511-51-0
1-Benzylindole-3-carboxaldehyde

: 118959-34-5
1-Benzyl-3-aminomethylindole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NH₂OH*HCl, 2.) acetic anhydride / 1.) pyridine, 85 deg C, 2.) reflux, 2 h

2: 90.5 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 12 h / Heating

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; acetic anhydride; In tetrahydrofuran; diethyl ether;
DOI:10.1007/BF00763270