Technology Process of (S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(methoxycarbonylamino)acetate
There total 7 articles about (S)-benzyl 2-((2R,6R)-2,6-dimethyltetrahydro-2H-pyran-4-yl)-2-(methoxycarbonylamino)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: copper(l) iodide / diethyl ether / 0.33 h / 0 °C / Inert atmosphere
1.2: 2.17 h / 0 - 20 °C
2.1: sodium tetrahydroborate; methanol / 1.17 h / 0 - 20 °C
2.2: 2.5 h / 20 °C
3.1: Chiralpak AD-H / n-heptane; ethanol; carbon dioxide / Resolution of racemate
4.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 8 h / 100 °C / Sealed vessel; Inert atmosphere
5.1: hydrogenchloride; water / tetrahydrofuran / 2 h
5.2: 4 h / 20 °C
With
hydrogenchloride; methanol; sodium tetrahydroborate; copper(l) iodide; water; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; ethanol; n-heptane; carbon dioxide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; methanol / 1.17 h / 0 - 20 °C
1.2: 2.5 h / 20 °C
2.1: Chiralpak AD-H / n-heptane; ethanol; carbon dioxide / Resolution of racemate
3.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 8 h / 100 °C / Sealed vessel; Inert atmosphere
4.1: hydrogenchloride; water / tetrahydrofuran / 2 h
4.2: 4 h / 20 °C
With
hydrogenchloride; methanol; sodium tetrahydroborate; water; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; n-heptane; carbon dioxide; toluene;
