cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide

Base Information

Chemical Name:cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide
CAS No.:1398110-62-7
Molecular Formula:C₂₀H₁₆Cl₃F₃N₂O₃
Molecular Weight:495.713
Hs Code.:

Synonyms:cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide

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Chemical Property of cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide

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Technology Process of cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide

There total 8 articles about cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6228-73-5
Cyclopropancarbamid

: 1398110-94-5
2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

: 1398110-62-7
cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide

Guidance literature:: With triethylsilane; trifluoroacetic acid; In toluene; for 23h; Reflux;

Reference yield:

: 21928-51-8
5-bromo-1,2,3-trichloro-benzene

: 1398110-62-7
cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide

Guidance literature:: Multi-step reaction with 7 steps

1: n-butyllithium / dichloromethane / 1.25 h / -78 °C / Inert atmosphere

2: lithium hydride / tert-butyl methyl ether; tetrahydrofuran / 1.5 h / 0 - 60 °C

3: triethylamine; trifluoroacetic anhydride / dichloromethane / 0.5 h / 20 °C

4: hydroxylamine hydrochloride; cesiumhydroxide monohydrate / dichloromethane / 1.5 h / 0 - 20 °C

5: diisobutylaluminium hydride / toluene; diethyl ether / 20 h / -5 - 20 °C / Inert atmosphere

6: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

7: trifluoroacetic acid; triethylsilane / toluene / 23 h / Reflux

With triethylsilane; manganese(IV) oxide; n-butyllithium; cesiumhydroxide monohydrate; hydroxylamine hydrochloride; lithium hydride; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene;

Reference yield:

: 158401-00-4
1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone

: 1398110-62-7
cyclopropanecarboxylic acid {2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]furan-3-ylmethyl}amide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydride / tert-butyl methyl ether; tetrahydrofuran / 1.5 h / 0 - 60 °C

2: triethylamine; trifluoroacetic anhydride / dichloromethane / 0.5 h / 20 °C

3: hydroxylamine hydrochloride; cesiumhydroxide monohydrate / dichloromethane / 1.5 h / 0 - 20 °C

4: diisobutylaluminium hydride / toluene; diethyl ether / 20 h / -5 - 20 °C / Inert atmosphere

5: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

6: trifluoroacetic acid; triethylsilane / toluene / 23 h / Reflux

With triethylsilane; manganese(IV) oxide; cesiumhydroxide monohydrate; hydroxylamine hydrochloride; lithium hydride; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene;