2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

Base Information

Chemical Name:2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde
CAS No.:1398110-94-5
Molecular Formula:C₁₆H₉Cl₃F₃NO₃
Molecular Weight:426.607
Hs Code.:

Synonyms:2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

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Chemical Property of 2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

Chemical Property:

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Technology Process of 2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

There total 8 articles about 2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398110-93-4
{2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]furan-3-yl}methanol

: 1398110-94-5
2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 158401-00-4
1-(3,4,5-trichloro-phenyl)-2,2,2-trifluoro-ethanone

: 1398110-94-5
2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydride / tert-butyl methyl ether; tetrahydrofuran / 1.5 h / 0 - 60 °C

2: triethylamine; trifluoroacetic anhydride / dichloromethane / 0.5 h / 20 °C

3: hydroxylamine hydrochloride; cesiumhydroxide monohydrate / dichloromethane / 1.5 h / 0 - 20 °C

4: diisobutylaluminium hydride / toluene; diethyl ether / 20 h / -5 - 20 °C / Inert atmosphere

5: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

With manganese(IV) oxide; cesiumhydroxide monohydrate; hydroxylamine hydrochloride; lithium hydride; diisobutylaluminium hydride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene;

Reference yield:

: 21928-51-8
5-bromo-1,2,3-trichloro-benzene

: 1398110-94-5
2-methyl-5-[5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-furan-3-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / dichloromethane / 1.25 h / -78 °C / Inert atmosphere

2: lithium hydride / tert-butyl methyl ether; tetrahydrofuran / 1.5 h / 0 - 60 °C

3: triethylamine; trifluoroacetic anhydride / dichloromethane / 0.5 h / 20 °C

4: hydroxylamine hydrochloride; cesiumhydroxide monohydrate / dichloromethane / 1.5 h / 0 - 20 °C

5: diisobutylaluminium hydride / toluene; diethyl ether / 20 h / -5 - 20 °C / Inert atmosphere

6: manganese(IV) oxide / dichloromethane / 18 h / 20 °C

With manganese(IV) oxide; n-butyllithium; cesiumhydroxide monohydrate; hydroxylamine hydrochloride; lithium hydride; diisobutylaluminium hydride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl methyl ether; toluene;