Technology Process of methyl 14-isopropyl-20,14-retro-retinoate
There total 5 articles about methyl 14-isopropyl-20,14-retro-retinoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / aq. 10percent KOH / propan-2-ol; ethanol / 1.25 h / 90 °C
2: 58 percent / MnO2, NaCN / acetonitrile; acetic acid / 62 h / 20 °C
3: 77 percent / aq. 5percent KOH / ethanol / 0.5 h / Heating
4: 1.) lithium diisopropylamide, HMPA / 1.) THF, hexane, -60 deg C, 5 min, 2.) THF, hexane, -70 deg C, 45 min
5: 89 percent / diethyl ether / 0.5 h / 0 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; manganese(IV) oxide; potassium hydroxide; sodium cyanide; lithium diisopropyl amide;
In
diethyl ether; ethanol; acetic acid; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm00081a020
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) lithium diisopropylamide, HMPA / 1.) THF, hexane, -60 deg C, 5 min, 2.) THF, hexane, -70 deg C, 45 min
2: 89 percent / diethyl ether / 0.5 h / 0 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide;
In
diethyl ether;
DOI:10.1021/jm00081a020
