Technology Process of ethyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
There total 6 articles about ethyl 2-(7-(3-cyano-4-isopropoxybenzyloxy)-8-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / toluene; tetrahydrofuran / 0.08 h / 20 °C
1.2: Reflux
1.3: 0.25 h / 180 °C / Microwave irradiation
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C
2.2: 2 h / 20 - 60 °C
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 °C
4.1: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere
5.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 65 °C
With
potassium tert-butylate; hydrogen; boron tribromide; sodium hydride; caesium carbonate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C
1.2: 2 h / 20 - 60 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 °C
3.1: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 65 °C
With
hydrogen; boron tribromide; sodium hydride; caesium carbonate;
palladium 10% on activated carbon;
In
ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: bromine; acetic acid / 48 h / 20 °C
2.1: bis(tri-t-butylphosphine)palladium(0) / tetrahydrofuran / 2 h / 65 °C
3.1: potassium tert-butylate / toluene; tetrahydrofuran / 0.08 h / 20 °C
3.2: Reflux
3.3: 0.25 h / 180 °C / Microwave irradiation
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C
4.2: 2 h / 20 - 60 °C
5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 20 °C
6.1: boron tribromide / dichloromethane / 1 h / 0 °C / Inert atmosphere
7.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 65 °C
With
potassium tert-butylate; hydrogen; bromine; boron tribromide; sodium hydride; caesium carbonate; acetic acid;
bis(tri-t-butylphosphine)palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
