(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Base Information

Chemical Name:(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran
CAS No.:156386-38-8
Molecular Formula:C₅₈H₆₄O₁₂
Molecular Weight:953.139
Hs Code.:

(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Synonyms:(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

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Chemical Property of (3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

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Technology Process of (3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

There total 6 articles about (3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 156386-37-7
(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran-6-ol

: 156386-36-6
(2S,3R,4S,5R,6R)-3,4-Bis-benzyloxy-6-benzyloxymethyl-2-fluoro-5-(4-methoxy-benzyloxy)-tetrahydro-pyran

: 156386-38-8
(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Guidance literature:: With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; silver perchlorate; tin(ll) chloride; In diethyl ether;
DOI:10.1016/S0040-4039(00)77002-X

Reference yield:

: 100-39-0
benzyl bromide

: 156386-38-8
(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TBAF, 2.) NaH / 1.) THF, 2.) DMF

2: 73 percent / SnCl₂, AgClO₄, 2,6-di-t-butylpyridine, 4A molecular sieves / diethyl ether

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; tetrabutyl ammonium fluoride; silver perchlorate; sodium hydride; tin(ll) chloride; In diethyl ether;
DOI:10.1016/S0040-4039(00)77002-X

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 156386-38-8
(3aR,5R,6R,7S,7aR)-7-Benzyloxy-5-benzyloxymethyl-6-[(2R,3R,4S,5R,6R)-3,4-bis-benzyloxy-6-benzyloxymethyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-b]pyran

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaOMe, 2.) (Bu₃Sn)2O, (n-Bu)4NBr, 3.) NaH / 1.) MeOH, 2.) benzene, reflux, 3.) DMF

2: dimethyl dioxirane / acetone

3: 1.) TBAF, 2.) NaH / 1.) THF, 2.) DMF

4: 73 percent / SnCl₂, AgClO₄, 2,6-di-t-butylpyridine, 4A molecular sieves / diethyl ether

With 2,6-di-tert-butyl-pyridine; 4 A molecular sieve; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium methylate; silver perchlorate; 3,3-dimethyldioxirane; sodium hydride; bis(tri-n-butyltin)oxide; tin(ll) chloride; In diethyl ether; acetone;
DOI:10.1016/S0040-4039(00)77002-X