2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol

Base Information

Chemical Name:2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol
CAS No.:1345532-35-5
Molecular Formula:C₂₀H₂₅NO₄S₂
Molecular Weight:407.555
Hs Code.:

Synonyms:2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol

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Chemical Property of 2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol

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Technology Process of 2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol

There total 4 articles about 2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₈F₃NO₅S₃

: 1345532-35-5
2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol

Guidance literature:: With sodium tetrahydroborate; sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 0.5h;

Reference yield:

: 1345532-34-4
2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

: 1345532-35-5
2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate; sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; triethylamine; In dichloromethane; water; 1: Pummerer reaction;

Reference yield:

: 1345532-33-3
4-bromomethyl-2,2-dimethyl-3-(4-methylphenylsulfonyl)-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

: 1345532-35-5
2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-(4R,5R)-1,3-oxazolan-5-ylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 1 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: sodium tetrahydroborate; sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; water; toluene; 2: Pummerer reaction;