2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

Base Information

Chemical Name:2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane
CAS No.:1345532-34-4
Molecular Formula:C₂₆H₂₉NO₄S₃
Molecular Weight:515.719
Hs Code.:

Synonyms:2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

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Chemical Property of 2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

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Technology Process of 2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

There total 1 articles about 2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1345532-33-3
4-bromomethyl-2,2-dimethyl-3-(4-methylphenylsulfonyl)-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

: 108-98-5
thiophenol

: 1345532-34-4
2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1345532-34-4
2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

: 407-25-0
trifluoroacetic anhydride

: C₂₈H₂₈F₃NO₅S₃

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1345532-34-4
2,2-dimethyl-3-(4-methylphenylsulfonyl)-4-phenylsulfanylmethyl-5-phenylsulfinylmethyl-(4R,5R)-1,3-oxazolane

: 1N-tert-butoxycarbonyl-1[2,2-dimethyl-(4R)-1,3-dioxolan-4-yl]-2-phenylsulfanyl-(1R)-ethan-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: sodium tetrahydroborate; sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 °C

3: camphor-10-sulfonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

4: dmap; triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5: magnesium / methanol / 6 h / 20 °C / Inert atmosphere; Sonication

With dmap; sodium tetrahydroborate; camphor-10-sulfonic acid; sodium hydrogencarbonate; magnesium; triethylamine; In methanol; dichloromethane; water; 1: Pummerer reaction;