N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide

Base Information

• Chemical Name: N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide
• CAS No.: 148806-56-8
• Molecular Formula: C₂₁H₂₁NO₆
• Molecular Weight: 383.401
• Mol file: 148806-56-8.mol

Synonyms:N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide

Chemical Property of N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide

There total 2 articles about N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

phthalic anhydride (85-44-9) + 3-(3,4-dimethoxyphenyl)alanine ethyl ester (148806-54-6) → N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide (148806-56-8)

Guidance literature:

at 150 ℃; for 1.5h;

DOI:10.1016/S0040-4020(01)87039-3

Reference yield:

4-bromomethyl-1,2-dimethoxybenzene (21852-32-4) → N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide (148806-56-8)

Guidance literature:

Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

2: 5percent HCl / 2 h / Ambient temperature

3: 63 percent / 1.5 h / 150 °C

With hydrogenchloride; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1016/S0040-4020(01)87039-3

Reference yield: 42.0%

N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide (148806-56-8) → 4-(3,4-Dimethoxy-phenyl)-1,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[c]azepine-3-carboxylic acid ethyl ester

Guidance literature:

In acetone; for 1.41667h; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(00)77616-7

upstream raw materials:

phthalic anhydride

3-(3,4-dimethoxyphenyl)alanine ethyl ester

4-bromomethyl-1,2-dimethoxybenzene