148806-54-6

Basic information

• Product Name: Tyrosine, 3-methoxy-O-methyl-, ethyl ester
• CAS NO: 148806-54-6
• Molecular Formula: C13H19NO4
• Molecular Weight: 253.298
• Mol File: 148806-54-6.mol

Chemical Properties

• CAS DataBase Reference: Tyrosine, 3-methoxy-O-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Tyrosine, 3-methoxy-O-methyl-, ethyl ester(148806-54-6)
• EPA Substance Registry System: Tyrosine, 3-methoxy-O-methyl-, ethyl ester(148806-54-6)

Safety Data

• Hazardous Substances Data: 148806-54-6(Hazardous Substances Data)

Upstream product

• 23234-41-5 L-Dopa ethyl ester hydrochloride 
• 55-59-4 3-(3,4-dimethoxyphenyl)-2-aminopropionic acid 
• 584-08-7 potassium carbonate 
• 23234-41-5 2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid ethyl ester; hydrochloride 
• 59-92-7 3,4-dihydroxy-L-phenylalanine 
• 128217-61-8 2-tert-Butoxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 
• 64-17-5 ethanol 
• 63-84-3 dopa 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 20583-78-2 ethyl (E)-3,4-dimethoxycinnamate 
• 911301-33-2 (E/Z)-ethyl 2-azido-3-(3,4-dimethoxyphenyl)acrylate 
• 128217-61-8 ethyl 2-(N-(tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propanoate 
• 13512-65-7 N-Benzyliden-3-<3,4-dimethoxy-phenyl)-alanin-ethylester 

Downstream Products

• 148806-56-8 N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide 
• 128217-61-8 ethyl 2-(N-(tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propanoate 
• 5796-17-8 D-Dopa 
• 33605-56-0 (R)-2-amino-3-(3,4-dimethoxyphenyl)propanoic acid 
• 128217-76-5 2-Allyloxycarbonylamino-3-(4,5-dimethoxy-2-nitro-phenyl)-propionic acid ethyl ester 
• 128217-65-2 2-Allyloxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 
• 500576-90-9 ethyl 3-(3,4-dimethoxyphenyl)-2-<[4-(isopropyloxy)-phenyl]carbonylamino>propionate 
• 76375-72-9 N-benzoyl-3,4-dimethoxy-phenylalanine ethyl ester 
• 128217-76-5 2-Allyloxycarbonylamino-3-(4,5-dimethoxy-2-nitro-phenyl)-propionic acid ethyl ester 
• 128217-65-2 2-Allyloxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 
• 132105-83-0 3,4-dimethoxy-N-phenylacetyl-phenylalanine ethyl ester 

Relevant articles and documents

The preparation method of the levodopa intermediate derivatives

The invention relates to a preparation method for a levodopa intermediate derivative. The preparation method comprises: in a solvent, reacting 3, 4-dimethoxybenzene phenylalanine shown as formula I with (+)-tartaric acid derivative to obtain the salt of a [(-)-3, 4-dimethoxybenzene phenylalanine]2.(+)- tartaric acid derivative. The solvent includes an alcohol solvent and an ester solvent. The racemization method includes: in the solvent, under the action of an aldehyde or ketone catalyst, reacting the 3, 4-dimethoxybenzene phenylalanine shown as formula I at 0-90DEG C for 0.5-24 h. The preparation method for the levodopa intermediate derivative provided by the invention has simple steps, and the prepared enantiomer has high purity and is low in cost, thus being applicable to industrial production. (reaction formula).

Synthesis of phenylalanine analogs

A straight forward synthesis of phenylalanine analogs is described. Cerium ammonium nitrate (CAN) mediated addition of azide to cinnamicester, followed by reaction with sodium acetate aff orded the α-azidocinnamate in moderate yield. Hydrogenation of α-azidocinnamate, followed by BOC, CBZ or Fmoc protection gave phenylalanine analogs. A new approach for synthesizing racemic p-boronophenylalanine analog was also explored.

FUSED-POLYCYCLIC COMPOUNDS

The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same.

Synthesis of 4-Aryl-2-benzazepine-1,5-diones by Photocyclization of N-(2-Arylethyl)phthalimides

The photocyclization of N-(2-arylethyl)phthalimides to 4-aryl-2-benzazepine-1,5-diones is described.We found that the presence of electron donating substituents on the aryl ring (as in 10a and b) is necessary for the cyclization process to occur.The procedure also allowed synthesis of 2-benzazepinediones with a carboxylate group at C3 (11c and d) which were obtained as 1:1 mixture of diastereoisomers.The results of irradiating phthalimides 12, which bear an oxygenated substituent at the benzylic position, depended on the nature of the substituent.Attempts to photocyclize N-(indan-2-yl)phthalimides 16 and the electron-rich phthalimide 23 failed.

Synthesis of the Chromophore of Pseudobactin, a Fluorescent Siderophore from Pseudomonas

Protected forms of dihydroxyphenylalanine (DOPA) were converted to the corresponding dihydroquinolin-2-ones 13 by nitration and reductive cyclization.Subsequent N-alkylation with α-halo-γ-aminobutyric acid derivatives provided the carbon framework 12 for the chromophore of pseudobactin.Conversion to protected forms of the fluorescent chromophore 5 was accomplished by reaction of 12 with Lawesson's reagent to produce the corresponding thioamide which was cyclized by reaction with mercuric acetate.

3-(3,4-Dihydroxyphenyl)-N-(4-nitrobenzyl)alanine hydrobromide

The compound of the formula: STR1 is active as an antibacterial agent.