148806-54-6

Basic information

• Product Name: Tyrosine, 3-methoxy-O-methyl-, ethyl ester
• CAS NO: 148806-54-6
• Molecular Formula: C13H19NO4
• Molecular Weight: 253.298
• Mol File: 148806-54-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Tyrosine, 3-methoxy-O-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Tyrosine, 3-methoxy-O-methyl-, ethyl ester(148806-54-6)
• EPA Substance Registry System: Tyrosine, 3-methoxy-O-methyl-, ethyl ester(148806-54-6)

Safety Data

• Hazardous Substances Data: 148806-54-6(Hazardous Substances Data)

Upstream product

• 55-59-4 3-(3,4-dimethoxyphenyl)-2-aminopropionic acid 
• 23234-41-5 2-Amino-3-(3,4-dihydroxy-phenyl)-propionic acid ethyl ester; hydrochloride 
• 128217-61-8 2-tert-Butoxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 
• 23234-41-5 L-Dopa ethyl ester hydrochloride 
• 63-84-3 dopa 
• 21852-32-4 4-bromomethyl-1,2-dimethoxybenzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 20583-78-2 ethyl (E)-3,4-dimethoxycinnamate 
• 911301-33-2 (E/Z)-ethyl 2-azido-3-(3,4-dimethoxyphenyl)acrylate 
• 128217-61-8 ethyl 2-(N-(tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propanoate 
• 13512-65-7 N-Benzyliden-3-<3,4-dimethoxy-phenyl)-alanin-ethylester 
• 59-92-7 3,4-dihydroxy-L-phenylalanine 
• 584-08-7 potassium carbonate 
• 64-17-5 ethanol 

Downstream Products

• 132105-83-0 3,4-dimethoxy-N-phenylacetyl-phenylalanine ethyl ester 
• 128217-76-5 2-Allyloxycarbonylamino-3-(4,5-dimethoxy-2-nitro-phenyl)-propionic acid ethyl ester 
• 76375-72-9 N-benzoyl-3,4-dimethoxy-phenylalanine ethyl ester 
• 5796-17-8 D-Dopa 
• 33605-56-0 (R)-2-amino-3-(3,4-dimethoxyphenyl)propanoic acid 
• 500576-90-9 ethyl 3-(3,4-dimethoxyphenyl)-2-<[4-(isopropyloxy)-phenyl]carbonylamino>propionate 
• 128217-76-5 2-Allyloxycarbonylamino-3-(4,5-dimethoxy-2-nitro-phenyl)-propionic acid ethyl ester 
• 128217-61-8 ethyl 2-(N-(tert-butoxycarbonyl)amino)-3-(3,4-dimethoxyphenyl)propanoate 
• 128217-65-2 2-Allyloxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 
• 128217-65-2 2-Allyloxycarbonylamino-3-(3,4-dimethoxy-phenyl)-propionic acid ethyl ester 
• 148806-56-8 N-<1-(ethoxycarbonyl)-2-(3,4-dimethoxyphenyl)ethyl>phthalimide 

Relevant articles and documents

The preparation method of the levodopa intermediate derivatives

The invention relates to a preparation method for a levodopa intermediate derivative. The preparation method comprises: in a solvent, reacting 3, 4-dimethoxybenzene phenylalanine shown as formula I with (+)-tartaric acid derivative to obtain the salt of a [(-)-3, 4-dimethoxybenzene phenylalanine]2.(+)- tartaric acid derivative. The solvent includes an alcohol solvent and an ester solvent. The racemization method includes: in the solvent, under the action of an aldehyde or ketone catalyst, reacting the 3, 4-dimethoxybenzene phenylalanine shown as formula I at 0-90DEG C for 0.5-24 h. The preparation method for the levodopa intermediate derivative provided by the invention has simple steps, and the prepared enantiomer has high purity and is low in cost, thus being applicable to industrial production. (reaction formula).

FUSED-POLYCYCLIC COMPOUNDS

The present invention provides a novel a condensed polycyclic compound useful as a phosphodiesterase 4 inhibitor, which is shown by the formula [I]: or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same.

Synthesis of the Chromophore of Pseudobactin, a Fluorescent Siderophore from Pseudomonas

Protected forms of dihydroxyphenylalanine (DOPA) were converted to the corresponding dihydroquinolin-2-ones 13 by nitration and reductive cyclization.Subsequent N-alkylation with α-halo-γ-aminobutyric acid derivatives provided the carbon framework 12 for the chromophore of pseudobactin.Conversion to protected forms of the fluorescent chromophore 5 was accomplished by reaction of 12 with Lawesson's reagent to produce the corresponding thioamide which was cyclized by reaction with mercuric acetate.