7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1059066-03-3
Molecular Formula:C₃₂H₂₆ClF₃N₂O₃
Molecular Weight:579.018
Hs Code.:

Synonyms:7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of 7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of 7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 9 articles about 7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1059066-02-2
7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1059066-03-3
7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: 7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

4-bromomethyltrifluoromethylbenzene; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1059066-03-3
7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetone / 18 h / Reflux

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

3.1: cesium hydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 - 20 °C

With cesium hydroxide; potassium tert-butylate; potassium acetate; potassium carbonate; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; acetone;

Reference yield:

: 4743-17-3
5-Chloroisatoic anhydride

: 1059066-03-3
7-chloro-5-(4-(4-methoxybenzyloxy)phenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 1.58 h / 18 - 28 °C

1.2: 19 h / 42 °C

2.1: acetic acid / 7 h / 130 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 16 h / 20 - 90 °C / Inert atmosphere

4.1: cesium hydroxide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

5.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 - 20 °C

With cesium hydroxide; potassium tert-butylate; sodium hydride; acetic acid; N,N-dimethyl-aniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; toluene;