Technology Process of 7-chloro-5-(4-hydroxyphenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
There total 8 articles about 7-chloro-5-(4-hydroxyphenyl)-1-methyl-3-(4-(trifluoromethyl)benzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; potassium iodide / acetone / 18 h / Reflux
2.1: potassium acetate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere
3.1: cesium hydroxide / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
4.2: 2 h / -78 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 3 h
With
hydrogenchloride; cesium hydroxide; potassium tert-butylate; potassium acetate; potassium carbonate; potassium iodide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran / 1.58 h / 18 - 28 °C
1.2: 19 h / 42 °C
2.1: acetic acid / 7 h / 130 °C
3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 16 h / 20 - 90 °C / Inert atmosphere
4.1: cesium hydroxide / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere
5.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
5.2: 2 h / -78 - 20 °C
6.1: hydrogenchloride / 1,4-dioxane / 3 h
With
hydrogenchloride; cesium hydroxide; potassium tert-butylate; sodium hydride; acetic acid; N,N-dimethyl-aniline; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; water; toluene;