3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde

Base Information

• Chemical Name: 3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde
• CAS No.: 1320259-65-1
• Molecular Formula: C₁₈H₁₉ClO₅
• Molecular Weight: 350.799
• Mol file: 1320259-65-1.mol

Synonyms:3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde

Chemical Property of 3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde

There total 3 articles about 3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-chloro-2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-78-6) + chloromethyl methyl ether (107-30-2) → 3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-65-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol201561w

Reference yield:

2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-48-0) → 3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride; tert-butylamine / toluene / 1 h / 70 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

With sulfuryl dichloride; tert-butylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;

DOI:10.1021/ol201561w

Reference yield:

2,4-dihydroxy-6-[(phenylmethoxy)methyl]-benzaldehyde (261958-55-8) → 3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-65-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 4 h / 25 °C / Inert atmosphere

2: sulfuryl dichloride; tert-butylamine / toluene / 1 h / 70 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

With sulfuryl dichloride; potassium carbonate; tert-butylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone; toluene;

DOI:10.1021/ol201561w

upstream raw materials:

2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde

3-chloro-2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde

chloromethyl methyl ether

2,4-dihydroxy-6-[(phenylmethoxy)methyl]-benzaldehyde

Downstream raw materials:

2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol

methyl 2-(2-carboxy-3-hydroxy-5-methylphenoxy)-4-chloro-3-hydroxy-5-methoxybenzoate

methyl 2-[2,6-bis(methoxymethoxy)-4-methylbenzoyl]-4-chloro-5-methoxy-3-methoxymethoxy-benzoat

C₂₂H₂₅ClO₁₀