2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol

Base Information

• Chemical Name: 2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol
• CAS No.: 1320259-67-3
• Molecular Formula: C₂₉H₃₅ClO₉
• Molecular Weight: 563.044
• Mol file: 1320259-67-3.mol

Synonyms:2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol

Chemical Property of 2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol

There total 4 articles about 2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-65-1) + 1,3-bis(methoxymethoxy)-5-methylbenzene (82265-37-0) → 2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol (1320259-67-3)

Guidance literature:

1,3-bis(methoxymethoxy)-5-methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 25 ℃; for 0.333333h; Inert atmosphere;

3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde; In tetrahydrofuran; hexane; at 0 - 25 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol201561w

Reference yield:

2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-48-0) → 2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol (1320259-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuryl dichloride; tert-butylamine / toluene / 1 h / 70 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 - 25 °C / Inert atmosphere

3.2: 4 h / 0 - 25 °C / Inert atmosphere

With n-butyllithium; sulfuryl dichloride; tert-butylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; toluene;

DOI:10.1021/ol201561w

Reference yield:

3-chloro-2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde (1320259-78-6) → 2,6-bis(methoxymethoxy)-α-[3-chloro-4-methoxy-2-methoxymethoxy-6-[(phenylmethoxy)-methyl]]-4-methyl-benzenemethanol (1320259-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 - 25 °C / Inert atmosphere

2.2: 4 h / 0 - 25 °C / Inert atmosphere

With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ol201561w

upstream raw materials:

3-chloro-4-methoxy-2-methoxymethoxy6-[(phenylmethoxy)methyl]-benzaldehyde

1,3-bis(methoxymethoxy)-5-methylbenzene

2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde

3-chloro-2-hydroxy-4-methoxy-6-[(phenylmethoxy)methyl]-benzaldehyde

Downstream raw materials:

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-4-methoxy-2-(methoxymethoxy)-6-[(phenylmethoxy)methyl]phenyl]-methanone

[2,6-bis(methoxymethoxy)-4-methylphenyl][3-chloro-6-hydroxymethyl-4-methoxy-2-(methoxymethoxy)phenyl]-methanone

C₂₂H₂₇ClO₉

C₂₂H₂₇ClO₈