(R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid

Base Information

Chemical Name:(R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid
CAS No.:1214265-77-6
Molecular Formula:C₂₄H₂₄FN₇O₃
Molecular Weight:477.498
Hs Code.:

Synonyms:(R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid

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Technology Process of (R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid

There total 6 articles about (R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1001346-91-3
4-amino-2-fluoro-5-methoxy-benzoic acid

: 1214265-75-4
(R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

: 1214265-77-6
(R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ISOPROPYLAMIDE; at 160 ℃; for 0.333333h; Microwave irradiation; Sealed tube;

Reference yield:

: 1214265-79-8
(6R)-3-chloro-6-ethyl-5-(propan-2-yl)-5,6-dihydroimidazo[1,5-f]pteridine-7-carbonitrile

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 1214265-77-6
(R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 48h; Closed vial;

Reference yield:

: 1001346-91-3
4-amino-2-fluoro-5-methoxy-benzoic acid

: 1214265-76-5
(R)-3-chloro-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridine-7-carbonitrile

: 1214265-77-6
(R)-4-(7-cyano-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-2-fluoro-5-methoxybenzoic acid

Guidance literature:: With N,N-dimethyl acetamide; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160 ℃; Microwave irradiation;
DOI:10.1016/j.bmcl.2016.10.009