2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:956011-31-7
Molecular Formula:C₁₇H₁₅FN₆O
Molecular Weight:338.344
Hs Code.:

Synonyms:2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 5 articles about 2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956010-93-8
4-(2,4-dimethoxybenzyl)-2-ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 956011-31-7
2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 16h; Reflux;

Reference yield:

: 256376-59-7
ethyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate

: 956011-31-7
2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / tetrahydrofuran; methanol / 4 h / 65 °C

2: dichloromethane / 16 h / 20 °C

3: sodium hydroxide / water / 16 h / Reflux

4: caesium carbonate / N,N-dimethyl-formamide

5: toluene-4-sulfonic acid / toluene / 16 h / Reflux

With caesium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.01.028

Reference yield:

: 956010-90-5
N-(2,4-Dimethoxybenzyl)-2-{[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]carbonyl}-hydrazinecarboxamide

: 956011-31-7
2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 16 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide

3: toluene-4-sulfonic acid / toluene / 16 h / Reflux

With caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2013.01.028