956010-90-5

Upstream product

• 956010-89-2 1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine-3-carbohydrazide 
• 93489-13-5 1-(isocyanatomethyl)-2,4-dimethoxybenzene 
• 256376-59-7 ethyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylate 

Downstream Products

• 956010-91-6 4-(2,4-dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 956010-92-7 4-(2,4-dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 956010-93-8 4-(2,4-dimethoxybenzyl)-2-ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 956011-07-7 4-(2,4-Dimethoxybenzyl)-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 956011-38-4 3-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-1,2,4-triazol-5(4H)-one 
• 956011-30-6 5-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 956011-31-7 2-Ethyl-5-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 956011-44-2 5-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 

Relevant academic research and scientific papers

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.

Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses

The present application relates to novel heterocyclyl-substituted fused pyrazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.